INHIBITION OF STAPHYLOCOCCAL ENTEROTOXIN B FORMATION BY CELL WALL BLOCKING AGENTS AND OTHER COMPOUNDS
Abstract
Enterotoxin B formation by Staphylococcus aureus S6 was inhibited by Tween 80, oleic acid, sodium deoxycholate, penicillin, D-cycloserine, or bacitracin. Toxin formation by strain 243 was sensitive to oleic acid, sodium deoxycholate, sodium lauryl sulfate, D-cycloserine, or bacitracin. The effect of D-cycloserine was reversed by D-alanine with strain 243 but not with strain S6. Neither penicillin nor bacitracin inhibited alpha-hemolysin or coagulase activity of strain S6; however, 0.118 micromoles of D-cycloserine per ml of liquid medium increased the alpha-hemolysin titer more than eightfold. Pigmentation of strain 243 was reduced by oleic acid, sodium deoxycholate, or methicillin and was completely inhibited by D-cycloserine or bacitracin. Glucose was required for the inhibition by spermine of valine-C14 incorporation into cellular protein of strain S6. It is suggested that these data indicate that the cell surface may contain sites important to the synthesis of enterotoxin B.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1968
- Accession Number
- AD0833372
Entities
People
- Mischa E. Friedman