THE NONSPECIFICITY OF THE INDIRECT HEMAGGLUTINATION REACTION IN DETECTION OF BOTULINE TOXINS IN FOODSTUFFS,
Abstract
To detect botulin in foodstuffs the indirect hemagglutination reaction was used. This reaction proved to be a rather rapid and sensitive method of laboratory diagnosis. It cannot, however, replace completely the biological test. In experiments with weak toxins this method appeared much more sensitive, as compared to the biological test, but in experiments with strong toxins it was inferior to the latter. With the aid of indirect hemagglutination reaction it was impossible to differentiate botulins of the A and B types. Besides, the same positive response was obtained in experiments both with botulins and toxoids of the A and B types, and with nontoxic filtrates of Cl. sporogenes, this being due to the presence in them of common somatic antigens. Thus, indirect hemagglutination reaction cannot be used for detecting botulin in foodstuffs. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1968
- Accession Number
- AD0833591
Entities
People
- T. I. Bulatova
Organizations
- United States Army Biological Warfare Laboratories