IMMUNOLOGICAL RESEARCH ON BASIC SPECIFIC AND NON-SPECIFIC PROTEIN ANTIGENS OF THE TYPE STREPTOCOCCUS PYOGENES (GROUP A)

Abstract

Immunoelectrophoresis and electrophoresis have confirmed that acid- alcohol gamma extracts contained several type specific and non-specific protein antigens which were basic proteins. Their isoelectric point is above 8.5, while that of the non-type specific proteins was higher than that of the M protein. They showed that the isoelectric point of M protein (about pH 9) extracted by the acid-alcohol method is very much greater than that of M protein extracted by the Lancefield method. This difference appears to indicate that the M protein is found in different states in the two extracts. In contrast, the migration of the non-type specific antigens is the same in the gamma and Lancefield extracts. Immunoelectrophoresis showed that the III alpha fraction, which is responsible for the retarded allergy, contains several antigens or several antigenic determinants.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 02, 1966
Accession Number
AD0833600

Entities

People

  • G. Drach
  • J. Goichot
  • R. Wahl

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Acids
  • Bacteria
  • Carbohydrates
  • Diffusion
  • Electrophoresis
  • Freund'S Adjuvant
  • Hydrochloric Acid
  • Migration
  • New York
  • Nucleic Acids
  • Polyethylene Glycols
  • Polysaccharides
  • Proteins
  • Reservoirs
  • Streptococcus
  • United States

Readers

  • Immunology