ANTIBODY FORMATION AFTER VACCINATION WITH MIXED VACCINES,
Abstract
Attempts to mix various antigens in a vaccine in order to keep the number of innoculations as low as possible have been going on for a long time. After a vaccine against diphtheria and tetanus was successfully introduced, the pertussis component was added to the DT-vaccine, also successfully, since infants and very young children are often innoculated against pertussis. After it became possible to make an anti-polio vaccine according to Salk's technique out of three types of formalin-activated viruses, triple and quadruple vaccines were introduced. This made it possible to vaccinate against polio, diphtheria and tetanus and optionally also against pertussis at the same time, and thus make innoculating easier. In considering the use of a quadruple vaccine for an official innoculation series, difficulties in making such a vaccine arose. The question was raised whether it would be possible to mix the individual elements of the quadruple vaccine and then to vaccinate. Even though no definite reports based on that kind of solution were known at that time, this procedure was cautioned against. It was recommended to give the individual components of the quadruple vaccine in four separate injections at one sitting. This paper shows how mixed vaccines differ in effect according to the way they are mixed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1966
- Accession Number
- AD0833604
Entities
People
- Heinrich Witzell
Organizations
- United States Army Biological Warfare Laboratories