EFFECT OF SUBLETHAL DOSES OF BOTULINAL TOXIN ON THE ORGANISM FOLLOWING MULTIPLE ADMINISTRATIONS

Abstract

The Cl. botulinum toxin administered repeatedly to guinea pigs, rabbits and mice provokes botulism and death with the sum total dose of the toxin administered being much below the lethal one. With a single administration of the total dose, the animals remained unaffected. Guinea pigs were more sensitive to manifold administration of botulinus A toxin in sublethal doses than rabbits and mice. When introducing small doses of the toxin, the vessels first showed an increased sensitivity with their immunity developing at a somewhat later date. Manifold administration of botulinus toxin in sublethal doses plays an important role in the pathogenesis of botulism.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1968
Accession Number
AD0833612

Entities

People

  • Konstantin I. Matveev

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Bacterial Toxins
  • Botulism
  • Commerce
  • Diseases And Disorders
  • Export Controls
  • Food Poisoning
  • Immunity
  • Lagomorphs
  • Lethal Dosage
  • Maryland
  • Pathogenesis
  • Poisoning
  • Rodents
  • Sensitivity

Fields of Study

  • Agricultural and Food sciences

Readers

  • Microbial Pathology
  • Public Financial Management and Budgeting