PRELIMINARY TRIALS TO ATTEMPT TO DETERMINE THE MODE OF ACTION OF ADJUVANT AND IMMUNITY-STIMULATING SUBSTANCES
Abstract
Alpha-chymotrypsin, administered intraperitoneally to experimental animals, does not damage development of antistaphylococcic immunity even when the toxoid is mixed with saponin, although in this case it entails a very definite lessening of the local reaction at the point of injection of the antigen. Using the staphylococcus toxoid + alpha-chymotrypsin mixture, the immunity obtained is a little weaker. Injection of the toxoid + saponin mixture gives a better immunity than toxoid alone. From this experimentation, whose purpose it was to find precisely the mode of action of adjuvant and immunity- stimulating substances, and in particular the influence of the local reaction at the point of injection of the antigen by using either generally or locally an anti-inflammatory, alpha-chymotrypsin, it appears that the proportion of antitoxin obtained does not always seem relative to the local reaction involved at the point of injection of the antigen. The same statement was made in the course of previous research on saponin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 07, 1966
- Accession Number
- AD0833615
Entities
People
- R. Richou
Organizations
- United States Army Biological Warfare Laboratories