INFLUENCE OF ACTINOMYCIN D ON THE RNA METABOLISM OF ANTIBODY-FORMING SPLEEN CELLS IN VITRO
Abstract
The inhibition of antibody synthesis in vitro by actinomycin D is accompanied by a definite reduction in the RNA synthesis. Both the nuclear RNA and the cytoplasmatic RNA are affected by this inhibition of synthesis. It is concluded that in spleen cells from immunized animals the synthesis of antibodies is preceded by the formation of a DNA-dependent RNA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 12, 1966
- Accession Number
- AD0834404
Entities
People
- Hans Kroeger
- Hermann Werchau
Organizations
- United States Army Biological Warfare Laboratories