A STUDY OF THE CORRELATION BETWEEN THE PATHOGENICITY OF VIRUSES OF THE TICK-BORNE ENCEPHALITIS GROUP FOR ANIMALS AND PECULIARITIES OF THEIR MULTIPLICATION IN THE ORGANISMS. REPORT 2. USE OF THE FLUORESCENT ANTIBODY METHOD TO DETECT AN UNINFECTIVE VIRAL ANTIGEN IN THE ORGANS OF ANIMALS INFECTED WITH THE MALAYAN LANGAT VIRUS (TR-21)
Abstract
By the fluorescent antibody method a marked viscerotropy and neurotropy of the Malaya Langat virus (TR-21 strain) could be established despite a weak pathogenicity of the virus for various animals inoculated intracerebrally of peripherally. The peculiarity of the pathogenesis of infection induced by the TR-21 strain consisted in the discrepancy between infection signs in cells (according to immunofluorescence) and the content of virus infective for mice therein. In many experiments carried out with mice, hamsters and pigs, the virus antigen, though of very low infectious titres, was demonstrable in many nervous cells. It is suggested that a low virulence of some viruses of this group, with peripheral inoculation, may be due to a weak viscerotropy of a strain or to the formation of noninfectious virus.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1965
- Accession Number
- AD0835147
Entities
People
- Kahn Shi-tsze
- V. V. Pogodina
Organizations
- United States Army Biological Warfare Laboratories