AN INVESTIGATION INTO THE GENETIC BACKGROUND OF PERNICIOUS ANEMIA BY AN IMMUNOLOGICAL METHOD
Abstract
In a group of 120 pernicious anemia patients antiparietal cell antibodies were found in 104 (87%) by means of the indirect immuno-fluorescence technique of Coons and Kaplan. These antibodies, which could be localized in the 7S gamma globulin fraction, were understood as auto-antibodies; they appear, in view of the high frequency with which they occur in cases of pernicious anemia, to be an essential manifestation of it. The corresponding antigen was localized by absorption techniques in the microsome fraction of a stomach homogenate. A study of the presence of antiparietal cell antibodies in members of the families of patients suffering with pernicious anemia produced a 20% positive result. On the basis of a clinical study of relatives with antibodies it appeared that the presence of the antibody may be thought of as an early symptom of a future gastritis; in the presence of antibody in relatives with no functional or morphological changes in the mucous membrane of the stomach an indication was found for atrophic gastritis as a basis for the auto-immune genesis of pernicious anemia.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 14, 1966
- Accession Number
- AD0835166
Entities
People
- A. Arends
- G. J. Anders
- H. O. Nieweg
- J. Abels
- K. Te Velde
Organizations
- United States Army Biological Warfare Laboratories