BLOOD FLOW STUDIES IN MAN IN SHOCK.
Abstract
Studies on total flow, nitritional flow, and non-nutritional (shunt) flow in skeletal muscle in the dog, using the rubidium extraction method, reveal that with hemorrhagic shock or soft tissue trauma, the normal inverse relationship between total flow and nutritional flow is preserved. Soft tissue trauma causes an immediate, transient, increase in non-nutritional flow, which is due to physiological shunting and not true A-V anastomotic shunting. A simple double-isotope method, which can be applied in man, has been described for the determination of the capillary permeability-surface area product (PS). This factor is reduced by locally applied nor-epinephrine and in shock, indicating a diminution in the size of the actively exchanging capillary bed. Studies on renal blood flow indicate that Angiotensin II is a powerful renal vasoconstrictor in man, that immunologic rejection in man is associated with very low blood flow, and that trauma in the dog does not increase shunt flow (Trueta phenomenon). Studies on liver blood flow indicate a good correlation between total flow and nutritional flow in the normal animal, and in man no effect on flow of glucagon. Studies on wound healing in the rabbit indicate a lag in the microcirculatory development at the critical period of tissue growth. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1968
- Accession Number
- AD0835882
Entities
People
- David H. Lewis
Organizations
- University of Gothenburg