THE EFFECT OF VITAMIN DEFICIENCIES ON THE IMMUNE RESPONSE TO SYNTHETIC POLYPEPTIDE ANTIGENS AND VACCINES IN SUB-HUMAN PRIMATES.
Abstract
Synthetic polypeptide-antibody precipitin curves indicate the presence of four multiple antigenic systems in the polypeptide. The primary antibody response in monkeys is resistant to methionine deficiency, methionine excess, and ethionine. The early secondary response is depressed both by ethionine and by methionine excess, and is resistant to methione deficiency. The late secondary response is resistant to methionine deficiency plus ethionine and to total protein deficiency. Monkeys that die from an anaphylactic reaction after the second injection of antigen have their major pathology in the liver. It is coagulation necrosis and hemorrhage. A number of nutritional deficiencies and metabolic antagonists were shown to depress the antibody response in rats: vitamin B6 deficiency, deoxypyridoxine, tryptophan deficiency, phenylalanine deficiency, ethionine, and methionine excess. Antibody production in genetically inbred rats varied with the genetic strain of the animals and with the structural characteristics of the antigen. Complexing the antigen with methylated bovine serum albumin abolished or reduced these interstrain differences. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1968
- Accession Number
- AD0835927
Entities
People
- Gustave J. Dammin
- S. J. Simonian
- Stanley N. Gershoff
- Thomas J. Gill Iii
Organizations
- Harvard Medical School