STUDY OF THE EFFECTS OF LYOPHILIZATION ON BILIARY CATATONIA

Abstract

The examination of the bile of eight patients suffering from mental troubles show that lyophilization in a general fashion clearly modified the pathogenic action of biles in animals. Certain biles producing catatonia before lyophilization lose this property after lyophilization. The same is true for the paralyzing and general toxic action, especially in cases 5 and 6 where the fresh bile caused paralysis and death of the animal before lyophilization while after lyophilization these same biles had no effect or else caused only a slight passing loss of initiative. The same is true of the high optical density of toxic biles; this optical density also goes down after lyophilization. These results favor the hypothesis that considers the biliary catatonia producing agent as a particularly fragile product.

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Document Details

Document Type
Technical Report
Publication Date
Jun 08, 1964
Accession Number
AD0836720

Entities

People

  • A. Vittoz
  • H. Baruk
  • M. Asfar

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Bile
  • Depression
  • Export Controls
  • Freeze Drying
  • Government (Foreign)
  • Governments
  • Heavy Metals
  • Jaundice
  • Liver Diseases
  • Maryland
  • Molecules
  • Movement Disorders
  • Neurobehavioral Manifestations
  • Paralysis
  • Smooth Muscle
  • Toxic Actions
  • United States

Readers

  • Computer Engineering
  • Educational Psychology
  • Toxicology/Environmental Toxicology