Thyroidal Dysfunction During Simulated Altitude Conditions

Abstract

Previous studies have indicated various degrees of thyroidal dysfunction in rats during exposure to high altitudes usually by simulated techniques. This study was undertaken to determine whether acute exposure to hypoxic conditions of simulated 15,000 ft. (429 mm Hg), exerts its effect on the trapping of 131 iodine and/or the processes of organification in the biosynthesis of thyroxine and its release from the thyroid gland of the rat. The data obtained in the present study indicated that the conversion of radiomonoiodotyrosine (MIT-131/I) to radiodiiodotyrosine (DIT-131/I) and the synthesis of radiothyroxine (T4-131/I) were significantly inhibited by hypoxia. In addition, total plasma radioactivity (131/I) and newly formed protein bound iodine (PB131/I) from hypoxic rats were significantly lower compared with control animals.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1968
Accession Number
AD0837153

Entities

People

  • Philip F. Jr Mulvey

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aerospace Medicine
  • Air Flow
  • Altitude
  • Animals
  • Barometric Pressure
  • Biomedical Research
  • Body Weight
  • Chromatographic Analysis
  • Endocrine Glands
  • Endocrinology
  • Glands
  • High Altitude
  • Hormones
  • Laboratory Animals
  • Military Research
  • Thyroid Glands
  • Thyroid Hormones
  • Thyroxine

Readers

  • Cardiovascular Physiology
  • Molecular and Cellular Biochemistry