THE EFFECTS OF ANTIBIOTICS, CORTICOSTEROIDS, AND PERITONEAL LAVAGE ON EXPERIMENTAL PERITONITIS,
Abstract
The effectiveness of antibiotics, corticosteroids and peritoneal lavage on experimental peritonitis in the rat depends upon the time of initiation of treatment. Compared with untreated controls, treatment with antibiotics was ineffective after 8 hours or 12 hours, and peritoneal lavage was totally ineffective 12 hours after the E. coli-hemoglobin inoculation. In contrast, dexamethasone provided protection even at 16 hours after inoculation. Combined treatments of dexamethasone and antibiotic or peritoneal lavage was no more effective than dexamethasone alone. However, the combined peritoneal lavage and kanamycin treatment at 12 hours after inoculation, increased survival significantly over a peritoneal lavage alone. The beneficial effects of dexamethasone could be attributed in part to increased peritonela absorption. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1968
- Accession Number
- AD0837171
Entities
People
- H. Kenneth Sleeman
- Harold F. Hamit
- John W. Diggs
Organizations
- Walter Reed Army Institute of Research