CULTIVATION OF VARIOLA VIRUS IN THE SUCKLING MOUSE
Abstract
Variola virus from human pustules and scabs was induced to grow intraperitoneally in suckling mice and was continued in sustained passages. It remained stable during 20 passages with respect to its biological properties in the chick embryo. One-day-old mice were more susceptible than 3-day animals. Variable resistance to variolar infection was seen among different mouse families. The virus propagated in more resistant animals without causing clinical manifestations. The lungs were a preferred organ for variola virus propagation. Infective variola virus was isolated from the lungs of infected, but clinically healthy mice for 45 days. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0837857
Entities
People
- A. Herrlich
- A. Mayr
Organizations
- United States Army Biological Warfare Laboratories