ACTION OF CHLORPROMAZINE (CPZ) ON EXPERIMENTAL POISONING AND INFECTION OF MICE WITH P. PESTIS (VACCINAL EV STRAIN),

Abstract

Chlorpromazine increases the severity of the intoxication in mice experimentally inoculated with plague toxin. Cortisone has but a very weak action on this harmful effect. On the other hand, chlorpromazine does not prevent the enhancement of virulence induced by cortisone in Pasteurella pestis infection. These findings show that the drugs should not be used in the treatment of human plague. (Author)

Document Details

Document Type
Technical Report
Publication Date
Nov 29, 1965
Accession Number
AD0838464

Entities

People

  • G. Girard
  • J. Gallut

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Bacterial Infections And Mycoses
  • Chlorpromazine
  • Diseases And Disorders
  • Gammaproteobacteria
  • Infection
  • Intoxication
  • Poisoning
  • Virulence
  • Wound Infections

Readers

  • Immunology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech