INTRACELLULAR MULTIPLICATION IN RELATION TO VIRULENCE IN MACROPHAGE GUINEA-PIG CULTURES OF SHIGELLA FLEXNERI,

Abstract

There is no significanct difference between these findings in tests with guinea-pig cells and those of Gerber and Watkins (1961) in their study of the course of a Shigella flexneri infection of a human cell strain (the 'Henle' strain, derived from embryonic intestinal epithelia). This means that the artificial laboratory conditions attendant upon tissue cultures in vitro banish numerous factors which are always present in the living specimen. This is further indication that Sh. flexneri (and the Shigella group in general) is preferentially parasitic upon man, and displays a positive tropism for intestinal tissue. (Author)

Document Details

Document Type
Technical Report
Publication Date
Jan 25, 1966
Accession Number
AD0838555

Entities

People

  • M. Cefalu
  • M. Saeli
  • P. Brancato

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Bacterial Infections And Mycoses
  • Biological Sciences
  • Cells
  • Cells (Biology)
  • Diseases And Disorders
  • Epithelium
  • Infection
  • Macrophages
  • Rodents
  • Tissue Culture
  • Tissues
  • Virulence
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology