IMMUNOLOGICAL STUDIES ON CRYPTOCOSSOSIS. REPORT III. STUDIES ON THE IMMUNOLOGICAL SPECIFICITY OF THE PROTEIN FRACTION AS ANTIGEN, AND ON THE DOSES OF THE POLYSACCHARIDE FRACTION FOR IMMUNOLOGICAL DIAGNOSIS
Abstract
It was found that the sensitivity of the protein fraction extracted from Cryptococcus neoformans as an antigen was inferior to that of the polysaccharide fraction as far as the precipitin or skin reaction was concerned. Not a single non-cryptococcosis patient demonstrated a positive reaction when their skin reactions were tested by the antigen, polysaccharide fraction of 2 mcg. or less in concentration and their precipitin reactions were examined with the antigen, of 500 mcg./ml. or less in concentration. So far, the investigation was not extended to clinical cryptococcosis. However, should a clinical cryptococcosis patient reveal positive skin or precipitin reaction in which the polysaccharide fraction is used as its antigen at an identical concentration as examined in nonclinical groups, it should be considered to be a valuable immunological diagnostic tool for crypotococcosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0838597
Entities
People
- Hasaku Yanai
Organizations
- United States Army Biological Warfare Laboratories