CHEMICAL BINDING OF PROTECTIVE AGENTS TO THE HUMAN STRATUM CORNEUM

Abstract

Report covers laboratory study and clinical trials on a series of chemical formulations to find means of chemically binding agents to skin elements or of permanent absorption to provide long term (7 days) protection from sunburn regardless of heavy sweating or washing actions. Results are reported in detail and tabulated. Two preparations were developed which were effective for long term exposure (4 hr) after single application and were resistant to washing action. Preparations did not interfere with tanning action and were cosmetically acceptable. Two were very effective under conditions of bright sun in dry climate or high elevation and snow environments. Stable binding to skin providing 7-day or longer protection was not achieved.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0839382

Entities

People

  • Madhukar A. Pathak
  • Thomas B. Fitzpatrick

Organizations

  • Harvard Medical School

Tags

DTIC Thesaurus Topics

  • Absorption
  • Abstracts
  • Alcohols
  • Altitude
  • Chemical Warfare Agents
  • Chemistry
  • Clinical Trials
  • Dermatologic Agents
  • Epidermis
  • Health Services
  • Light Sources
  • Medical Personnel
  • Methanols
  • Photosensitivity Disorders
  • Solar Radiation
  • Sweating
  • Ultraviolet Radiation

Readers

  • Materials Science
  • Molecular and Cellular Biochemistry
  • Oncology