IMMUNITY OF WHITE MICE TO EEE VIRUS. REPORT NO. 7. FURTHER INVESTIGATIONS OF THE ROLE OF INTERFERENCE IN CEREBRAL IMMUNITY
Abstract
An attempt is made to explain the resistance of EEE-immune mice to intracerebral challenge with VEE-virus serologically different from the EEE- virus on the basis of an interference phenomenon. When mice which had been passively immunized with homologous EEE-hyperimmune serum were shortly afterwards given intracranial experimental infection with a large dosage (about .000001 LD) of EEE-virus and eight or ten days later were given intracranial decimal solutions of VEE virus, a mutual interference was found between the two serologically different virus strains. While 80% of control animals not infected with VEE virus became ill at a later time from EEE, those which were given superinfections intracranially with .01 to .001 LD50 of VEE virus did not show any EEE illness at a later date. An autosterilization of the brain evidently took place in the absence of any specific antibodies. The significance of interference phenomena as a factor in immunity is discussed in connection with EEE and other animal virus diseases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 18, 1964
- Accession Number
- AD0839387
Entities
People
- Erich Traub
Organizations
- United States Army Biological Warfare Laboratories