ANTIDOTE ACTION OF BIS-(4-HYDROXYIMINOMETHYL PYRIDINIUM-(1)-METHYL)- ETHER DICHLORIDE IN RATS POISONED BY ALKYLPHOSPHATE

Abstract

The antidote efficacy of bis-4-hydroxyiminomethyl pyridinium-(1)- methyl-ether dichloride (LueH6, Toxogonin) against alkylphosphate poisoning in rats was tested in vivo and in vitro. Paperchromatic analyses indicated the restoration of cholinesterase activity in the brain, serum and liver when LueH6 was used prophylactically after the rats were poisoned by 0,0'-diethyl-p- nitrophenylphosphate (Paraoxon) and 0,0'-diisopropylfluorophosphate (DFP). The tolerance of LueH6 was 150 mg/kg of body weight. The LD50 was 215 mg/kg of body weight. Effective antidote activity was obtained by using 1/6th of the lethal dose. Within the limits of tolerance, no irreversible histological changes were observed.

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Document Details

Document Type
Technical Report
Publication Date
Jul 25, 1967
Accession Number
AD0840894

Entities

People

  • E. Zoch
  • G. Fischer
  • H. Oldiges
  • K. Bisa
  • O. Mueller

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Acids
  • Antidotes
  • Blood
  • Body Weight
  • Central Nervous System
  • Hydrolysis
  • Lethal Dosage
  • Liver
  • Nervous System
  • Parathion
  • Phosphoric Acids
  • Poisoning
  • Respiration
  • Substrates
  • Tissue Extracts
  • United States

Fields of Study

  • Biology
  • Chemistry

Readers

  • Neurotoxicology
  • Toxicology/Environmental Toxicology