FURTHER DIFFERENCES BETWEEN CONGLUTINATION AND AGGLUTINATION
Abstract
By heating for a duration of 1/2 hour at 56C bovine serum loses its agglomeration property against several microbes. The agglomeration appears again if one replaces the alexin, inactivated by the heating, by some other more agglutinating alexin containing serum from guinea pigs, rabbits, horses or men. This property of agglomeration of bovine serum also disappears if one destroys the alexin by means of distilled water or if one removes the alexin of the bovine serum by prior contact with sensitive blood corpuscles, goat blood corpuscles, but it is formed again by addition of fresh alexin. This agglomeration does not appear in spite of the presence of alexin when the bovine serum due to prior contact with corresponding microbes becomes deprived of its effective sensitizer, but arises even under these conditions if the removed bovine sensitizers are replaced by corresponding immunity sensitizers. In some combinations the removed bovine sensitizers are replaced by normal sensitizers which exist in the serum which is used as the alexin source. This agglomeration of the microbes is not changed with agglutination. In order to distinguish between the latter and the usual agglutination the name conglutination was proposed for this special agglomeration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0841607
Entities
Organizations
- United States Army Biological Warfare Laboratories