THE SMOOTH TO ROUGH FORM CHANGE IN BACTERIUM TYPHI
Abstract
A parallel exists between outward smooth characteristics and antigen structure of Bacterium typhi. Strains which contain either O or Vi-Antigens, and therefore more strains containing both O and Vi-Antigen, are not autoagglutinable and usually have a smooth colony form. Strains which have O- Antigen or O and Vi-Antigen are autoagglutinable and have a rough colony form. No factors may create outwardly smooth characteristics in typhus bacteria, in the absence of these two antigens. A plan of smooth-rough form change which indicates these relationships was set up. Secondary cultures, created by addition of Vi-Bacteriophages to strains containing Vi and O-Antigen, are not agglutinable and have a smooth colony form. Secondary cultures, created by addition of Vi-Bacteriophages to strains containing Vi and no O-Antigen, are autoagglutinable and have a rough colony form, even when the original strain was not only stable in table salt solution but also a smooth colony form.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1955
- Accession Number
- AD0841623
Entities
People
- R. T. Scholtens
Organizations
- United States Army Biological Warfare Laboratories