IMMUNITY TO ANTHRAX
Abstract
The immunity of rabbits inoculated with sterilized edematous fluid fails to show any connection with the capsular antibody. The author was unable to demonstrate capsular antibody in the blood of immunized animals; attempts to neutralize the immunity of the animals with purified capsular antibody failed. Mice inoculated with 1 cc of blood serum of an immunized rabbit failed to show an important increase in resistance to anthrax infection over untreated controls. Rabbits may be successfully immunized with the non-capsular R variant of the anthrax bacillus, as noted also by Stamatin and Stamatin, as well as by Sterne. Rabbits may also be successfully immunized with the edematous fluid of guinea pigs killed by infection with the R variant; this edematous fluid fails to reveal the specific substance of the anthrax bacillary capsule even by use of very sensitive serologic tests. Mice could not be immunized wither with the edematous fluid or with large quantities of killed, encapsulated anthrax bacilli.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0841872
Entities
People
- G. Ivanovics
Organizations
- United States Army Biological Warfare Laboratories