The Sensitivity of Guinea Pigs to Penicillin

Abstract

The studies provide an insight into the significance of nutritive factors in the pathogenesis of toxic effects of penicillin. In practice, elimination of green fodder (cauliflower leaves) leads to a reduction in penicillin tolerance which is, however, not solely due to a lack of Vitamin C, since even manifold overdosage of ascorbic acid does not compensate the complex of toxic symptoms which develops through omission of green fodder. It can be surmised that cabbage leaves contain specific effective substances which are able to raise the limit of tolerance of guinea pigs towards penicillin. Tissue water deprivation caused by withdrawal of green fodder cannot in itself be decisive since the addition of fluids in the form of oatmeal gruel causes only a temporary increase in weight which is again followed by weight loss.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 20, 1967
Accession Number
AD0843483

Entities

People

  • H. Grimmer

Organizations

  • United States Army Biological Warfare Laboratories

Tags

DTIC Thesaurus Topics

  • Animals
  • Anti-Bacterial Agents
  • Body Weight
  • Laboratory Animals
  • Pathogenesis
  • Rodents
  • United States
  • Vitamin C
  • Vitamins
  • Water Deprivation
  • West Germany

Readers

  • Microbial Pathology
  • Systems Analysis and Design
  • Trauma Surgery or Emergency Medicine.