An Infectious Subtype of the Nature of Ribonucleic Acid from Brains of Mice Infected with Yellow Fever Virus
Abstract
Ribonucleic acid, with a 0.03% infectiosity of the original virus, was obtained by phenol extraction from the brains of mice infected with yellow fever. The preparation displayed the UV absorption that is characteristic of nucleic acids. Protein admixtures were not detectable with the biuret test. Ribonuclease, trypsin and also serum globulin inhibited the infectiosity. Deoxyribonuclease, chymotrypsin and ethanol were without effect. The inhibitory action of trypsin is discussed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1963
- Accession Number
- AD0843856
Entities
People
- G. Neilsen
- J. Marquardt
Organizations
- United States Army Biological Warfare Laboratories