Cytotoxicity of Virus
Abstract
Cytotoxic effects through virus capable of propagation such as those of the pox group inactivated by ultraviolet exposure, were produced under high virus-cell ratios in various cell cultures. In the inoculated culture systems, these effects do not propagate in stages and cannot be transferred to new cultures. The cytotoxic effect was linked to the virus particles. The 'changed' cultures do not show any observable virus propagation. Comparison of three members of the pox group, in relation to cytotoxicity and virus propagation in various cultures, indicates that the cells propagate virus to greater or lesser extent or not at all whereas the conditions for cytotoxicity are very probably uniform in all members of the group. There was no correlation between these two virus effects. In regard to virus propagation, the individual types are different from each other in different cell systems but act uniformly in regard to cytotoxicity, independently of the cell system.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 03, 1968
- Accession Number
- AD0843865
Entities
People
- Helmut Mahnel
Organizations
- United States Army Biological Warfare Laboratories