The Development of Mutations of Tobacco Mosaic Virus by the Chemical Treatment of its Nucleic Acid in Vitro

Abstract

In order to demonstrate the genesis of mutants in vitro, conditions were chosen under which a strong increase occurs in the number of necrotic lesions caused by the mutants on Java tobacco. Owing to this increase, the number of mutants multiplies 20 times over the original value in an area where the infectivity has decreased by only one half. This precludes selective processes. Nor may the rise be attributed to a higher degree of probability of the mutants' assertiveness due to dilution or inactivation, as frequently noted (Mundry 1957 a). Therefore the mutants were induced by treatment with nitrite.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1968
Accession Number
AD0843942

Entities

People

  • A. Gierer
  • K. W. Mundry

Organizations

  • United States Army Biological Warfare Laboratories

Tags

Communities of Interest

  • C4I

DTIC Thesaurus Topics

  • Dilution
  • Equations
  • Export Controls
  • Government (Foreign)
  • Governments
  • Incubation
  • Infection
  • Materials
  • Mutations
  • Necrosis
  • Nucleic Acids
  • Nucleotides
  • Particles
  • Personality
  • Virion
  • Viruses
  • West Germany

Fields of Study

  • Biology

Readers

  • Calculus or Mathematical Analysis
  • Microbial Pathology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology