Interference Among Group A Arboviruses

Abstract

Interference among group A arboviruses that did not involve the mediation of interferon is described. Interference was observed only if the interfering virus had an advantage over the challenge virus either in time or in multiplicity of infection. Adsorption, penetration, and uncoating of challenge virus did not appear to be inhibited, but the synthesis of infectious viral RNA of the challenge virus was significantly retarded. With temperature-sensitive viruses or mutants, the replication of viral RNA by the interfering virus was required to establish interference. A mechanism of interference based on a competition for replication sites or substrates was compared with other possible explanations.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1968
Accession Number
AD0844170

Entities

People

  • Arthur Brown
  • Eugene Zebovitz

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Arbovirus Infections
  • Arboviruses
  • Biological Sciences
  • Chemistry
  • Culture Techniques
  • Encephalitis
  • Equine Encephalitis
  • Infection
  • Interferon
  • Mouth Diseases
  • Proteins
  • Ribonucleic Acids
  • Virus Diseases
  • Viruses
  • Yellow Fever
  • Zoonoses

Fields of Study

  • Biology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Virology (or Medical Virology).