Synthesis of the Immune-Specific, Polypeptide-Like Hapten of the Anthrax-Subtilis Bacilli Group. A Synthetic Proof of the Constitution of Natural Polyglutamic Acids
Abstract
The synthesis of three stereo-isomeric gamma-polyglutamic acids were phased as follows. At first the dimethylester of the corresponding steric series was synthesized. Then the bifunctional start dipeptides, by means of a previous activation of their carboxyl group or amino group, were subjected to intermolecular polyacylation. The polyester was subjected to alkaline saponification, then the polyacid was separated first in form of its difficulty soluble copper salt, liberated from the latter by hydrogen sulphide, purified by means of dialysis and thus freed of lower oligopeptides, and finally produced from the solution by freeze drying.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0845962
Entities
People
- H. Nagy
- J. Kovacs
- J. Wein
- M. Kajtar
- V. Bruckner
Organizations
- United States Army Biological Warfare Laboratories