Cultivation of Yellow Fever Virus in Human Explants
Abstract
It is deduced from tentative results of pathogenicity tests with monkeys, that strain 17 D has not lost its original quality after more than 145 passages through human explants. A reversion to the viscerotropic form, such as the one apparently achieved by Findlay and Clarke by monkey liver passage of the French neurotropic strain, could not be demonstrated. The loss of viscerotropy shown by the pantropic Asibi strain is noteworthy because it proved the independence of this mutation from the species-specific origin of the explanted tissue, i.e. it takes place also in tissue explants of the natural host.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1968
- Accession Number
- AD0846558
Entities
People
- C. Hallauer
Organizations
- United States Army Biological Warfare Laboratories