Study of the Physiological Chemical Mechanisms of the Toxic Action of Hydrazines. The Effects of Hydrazines on Rat Brain 5-Hydro-oxytryptamine, Norepinephrine, and Gamma-aminobutyric Acid.
Abstract
The influence of hydrazine (HY), monomethyl hydrazine (MMH), 1,1-dimethyl hydrazine (UDMH) and 1,2-dimethyl hydrazine (SDMH) was studied upon possible transmitter substances in rat brain, at times calculated to just precede convulsions. Mesencephalon-diencephalon, medulla, cortex and cerebellum were separately examined. All the hydrazines increased 5-hydroxytryptamine (5HT), particularly in cortex, where a 3-fold increase was found. All the hydrazines increased norepinephrine (NE) by small amounts (48% maximum), the effects being greatest in cortex and least in mesencephalon-diencephalon. MMH, UDMH and SDMH lowered gamma-aminobutyric acid (GABA) by small amounts (17% maximum) in medulla, cortex and cerebellum, but effects on mesencephalon-diencephalon were small or absent. HY raised GABA in all parts, especially in cortex (31%). Since the non-toxic SDMH showed all of the above effects to the same extent as the toxic hydrazines, it is unlikely that these effects are causally involved in toxicity of these agents. An exception may be the effect of HY in raising GABA levels. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1963
- Accession Number
- AD0846926
Entities
People
- Pearl S. Miller
- Richard D. O'brien
- Tetsuo Uchida
Organizations
- Cornell University Department of Entomology