Toxicity of O-Chlorobenzylidene Malononitrile (CS) in Trioctylphosphate (TOF) Solutions

Abstract

As solutions containing 1% o-chlorobenzylidene malononitrile (CS) in trioctylphosphate (TOF) have been proposed for use in riot control situations, a series of toxicological tests was conducted in animals. Results showed that the doses tested are not permanently injurious to the eyes. Effects on skin ranged from none to necrosis, and the affected ares usually healed within 2 weeks. When the mixtures were directly injected into the trachea, some evidence of congestion and pneumonia was seen. But the severity and duration of signs were not in a category that would warrant veterinary treatment under conditions of normal animal care. The reported studies indicate that no irreversible damage is expected with 1% CS/TOF solutions as long as the dose ranges shown to be safe in this paper are not exceeded.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1969
Accession Number
AD0850248

Entities

People

  • E. J. Owens
  • J. F. Ferrell
  • J. S. Everts
  • J. T. Weimer
  • T. A. Ballard

Tags

DTIC Thesaurus Topics

  • Animals
  • Blood
  • Cell Count
  • Cells
  • Chemical Warfare Agents
  • Chlorides
  • Conjunctival Diseases
  • Experimental Design
  • Hair
  • Materials
  • Medical Personnel
  • Physical Properties
  • Riot Control
  • Riot Control Agents
  • Rodents
  • Skin Diseases
  • Tissues

Readers

  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.
  • Toxicology/Environmental Toxicology