On the Serological Specificity of Subunits of Two Arboviruses of Group A (Sindbis and WEE) (Ueber die Serologische Spezifitat von Untereinheiten Zweier Arboviren der Gruppe A (Sindbiss und WEE)
Abstract
The serological specificity of four subunits of Sindbis and WEE virus was investigated in cross-reactions. The four subunits were: 'complete' virus particles, the 'hemagglutinin,' and the so-called 1.300- and 1.345-'cores.' In neutralization studies, a uni-directional relationship between Sindbis and WEE virus was demonstrated, in which Sindbis antibodies neutralized Sindbis and WEE virus, whereas WEE antibodies reacted with the homologous virus only. An analogous relationship was also found in the CF reaction with 1.300- and 1.345 'cores,' especially with the latter. On the other hand, 'complete' virus particles and 'hemagglutinin' showed clear-cut cross-reactions when used in CF reactions. The results are discussed in relation to the antigenic structure of the two viruses and to the uni-directional relationship which has been demonstrated for certain subunits.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1969
- Accession Number
- AD0850509
Entities
People
- M. Mussgay
Organizations
- United States Army Biological Warfare Laboratories