Note on the Synthesis of C-Toxiferin-I from Wieland-Gumlich-Aldehyde Comparison of Toxicity of Synthetic and Natural Curare-Alkaloids
Abstract
A good preparative method is described to produce C-toxiferin-I from Wieland-Gumlich-aldehyde: Selfcondensation of Nb-methyl-Wieland-Gumlich Aldehyde to C-toxiferin-I, diacetyl C-toxiferin-I, and Nb-dimethylcaracurin-V; Conversion of Nb-dimethylcaracurin-V in the reaction mixture to C-toxiferin I, and diacetyl C-toxiferin I via toluensulfonic acid and in HAS; Saponification of diacetyl-C-toxiferin I. The toxicity of the synthetic alkaloids C-toxiferin I, Nb-dimethylcaracurin-V, C-dihydro toxiferin, and dihydro toxiferin-I* was tested and compared to the corresponding natural alkaloids. The toxicities of the synthetic and natural compounds were very similar.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1969
- Accession Number
- AD0850513
Entities
People
- F. Berlage
- Heinz Schmid
- Karl Bernauer
- P. Karrer
- P. Waser
- W. Von Philipsborn
Organizations
- United States Army Biological Warfare Laboratories