Use of N-Acetylcolchamine as a Mitotic Poison
Abstract
The anti-mitotic activity of N-acetylcolchamine on Ehrlich ascites cancer cells has been studied in vivo in mice. It has been established that N-acetylcolchamine is an inhibitor of mitosis which, like colchicine, is able to block cell division at the stage of metaphase. Since N-acetylcolchamine is more readily available than colchicine, and is easily obtained in a chemically pure state by acetylation of colchamine, it is recommended for use in various biological studies in place of colchicine.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 22, 1969
- Accession Number
- AD0851843
Entities
People
- F. Y. Zusman
- N. N. Myshkin
- O. V. Khmelevskiy
- V. I. Khmelevskiy
Organizations
- United States Army Foreign Science and Technology Center