An Evaluation of the Irritant Potential of CS Aerosols on Human Skin under Tropical Climatic Conditions
Abstract
An attempt was made to quantitate the irritant potential of (o-chlorobenzylidene)malononitrile (CS) aerosols on human skin. A 'negative patch test' was devised to expose small areas of the forearm to the agent in a subchamber assembly simulating tropical and temperate climates. Graded responses were obtained by unsheathing each area at intervals, and responses were read 24 hours after exposure. It was found that it is virtually impossible to predict the dose of CS that will cause minimal erythema in an untested individual under tropical conditions because the variations among individuals are so great. It is estimated that 50% of a large group of men will develop some degree of erythema when the Ct of CS is about 3,500 mg min/cu m and the climate is tropical. It was also found that CS may produce sensitization and delayed skin response.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1969
- Accession Number
- AD0853967
Entities
People
- Alfred Hellreich
- John T. Weimer
- Kragg P. Kysor
- Millard M. Mershon
- Nicholas G. Bottiglieri