Chronic Disabling Dermatoses

Abstract

Free fatty acids (FFA) liberated from sebum have been implicated in the pathogenesis of acne. To determine the lipase producing organisms three studies were performed. In the first, the scalp was treated topically with neomycin to eliminate aerobic cocci. No change in the percentage of free fatty acids occurred. Next, subjects received oral demethylchlortetracycline to abolish C. acnes. Those subjects with high FFA responded with a 50% reduction. The third study used topical amphotericin B to reduce yeasts (Pityrosporum) and the values for FFA are now being determined. Quantitative bacteriology and Baird Parker classification of the cocci in acne comedones showed the numerical preponderance of C. acnes. The cocci were almost always SII. Athletes' foot has been examined with reference to the total microflora. A method for sampling the 4th interspace has been tested. Bacteria play a considerable role in the clinical appearance and course of this basically fungal condition. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1970
Accession Number
AD0874484

Entities

People

  • Albert M. Kligman
  • Richard R. Marples

Organizations

  • University of Pennsylvania

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Bacteria
  • Bacteriology
  • Biomedical Research
  • Department Of Defense
  • Diseases And Disorders
  • Drug Abuse
  • Fatty Acids
  • Fungi
  • Head (Anatomy)
  • Health Services
  • Infection
  • Lipids
  • Microbiology
  • Microorganisms
  • Retinoic Acids
  • Skin Diseases

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