Sustained Protection against Superficial Bacterial and Fungal Infections by Topical Treatment
Abstract
The feasibility of providing sustained protection of the skin against infection by common micro-organisms has been shown in previous reports. Some antimicrobial agents remain active and persistent on human skin. Neomycin reduces growth of the flora under occlusion at a dose of 0.4 micrograms per sq. cm. Neomycin, chloramphenicol and some other drugs will reduce the high numbers of organisms created by preocclusion. Experimental infections with 'Staphylococcus aureus' on mildly traumatized skin have been extensively investigated. By delaying inoculation of the pathogen until 24 hours after injury a safe yet realistic infection can be produced. The requirements for a valid test of antibacterial action are still in doubt but the ability of the test to detect effective antibacterial action is not doubted. Similarly basic studies of the 'Candida albicans' infection model have indicated the safety repeatability and practical value of this test. Infections with 'Pseudomonas' can now be created but repeatability remains a problem. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1972
- Accession Number
- AD0903316
Entities
People
- Albert M. Kligman
- Richard R. Marples
Organizations
- University of Pennsylvania