Development of Mosquito Repellents Having Increased Protection Time in Man.
Abstract
The experiments reported are the result of close cooperation between groups at Stanford Research Institute and the University of California, San Francisco Medical Center. The former group synthesizes potential topical repellents. The latter group assays new compounds for repellency in man and conducts behavioral studies with mosquitoes. Synthetic topical repellents were prepared, following previously reported leads that resulted from intrinsic repellency studies and from SRI computer-coded USDA compounds. The most promising structural area for topical repellency is that of glycol ether derivatives, although the sulfonamide, oxo-rhodanine, and quinoxaline areas are also of interest. Efforts were made to rationalize differences in results obtained by various laboratories using different test methods. Polymer formulation of the SRI glycol ether greatly improved its water wash-off characteristics and its duration on the skin. It is expected that more formulation studies can enhance these characteristics even further and improve the cosmetic acceptability. Bulk samples of two Russian repellents and of the SRI C6 glycol ether were synthesized and submitted to the Army for extensive toxicologic and field testing. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 15, 1973
- Accession Number
- AD0910519
Entities
People
- H. C. Tong
- Howard L. Johnson
- W. A. Skinner
Organizations
- SRI International