Recombination and Transmission Studies with Influenza Virus.
Abstract
Continued studies of temperature sensitive (ts) mutants have been productive in more precise definition of the genetic lesion with respect to viral function. Intensive study of two neuraminidase deficient (NA-) mutants have produced striking evidence of the aggregation of such mutants that occurs apparently as a consequence of failure of the defective enzyme to split neuraminic acid from the particles as they emerge from the infected cell. Comparative studies of two viral variants that are NA+ and NA- with respect to neuraminidase content and activity have demonstrated interesting differences in the replication of these viruses in different cell systems. Application of viral genetics to improvement of influenza vaccines, isolation and characterization of influenza viral polypeptides, and studies of influenza viral replication and its inhibition are described.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1974
- Accession Number
- AD0921974
Entities
People
- Edwin D. Kilbourne
Organizations
- Icahn School of Medicine at Mount Sinai