Endocannabinoids as a Target for the Treatment of Traumatic Brain Injury
Abstract
The results from our ongoing studies during this funding period have provided evidence that EC enzyme degradation inhibitors are effecting at reducing astrocyte and microglial activation at 24hrs post-TBI. In addition, perfusion fixed brains with one dose of the EC enzyme degradation inhibitors at 7 and 30 day post-TBI will undergo immunostaining to evaluate the injury lesion size and detection of activation of astrocytes and microglia, as well as neuronal cell death and density. Finally, oxidative stress related mRNA and protein expression will be measured in samples obtained 72 hrs post-TBI following two doses of the ECenzyme degradation inhibitors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2014
- Accession Number
- AD1000064
Entities
People
- Patricia E. Molina
Organizations
- Louisiana State University