DHHC3 Contributions to Breast Cancer
Abstract
Protein palmitoylation, more accurately termed as protein S-acylation, is reversibly regulated by a group of Asp-His-His-Cys(DHHC) motif-containing palmitoyl acyltransferases (PATs) and several acylprotein thioesterases (APTs) (1). Its primary function is to regulate the spatial cycling of proteins between different compartments of cells, and thus to modulate protein activity and stability as well as multiprotein complex formation (1). By developing and applying unbiased palmitoyl-proteomics technologies, we and others showed that many palmitoylated proteins are enriched in cholesterol-rich membrane microdomains such as lipid rafts and tetraspanin-enriched microdomains (TEMs) (2).
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2014
- Accession Number
- AD1000362
Entities
People
- Michael R Freeman