Wnt/beta-Catenin, Foxa2, and CXCR4 Axis Controls Prostate Cancer Progression

Abstract

Wnt/beta-Catenin signaling and associated target genes are implicated in the establishment of bone metastasisand in the development of castration resistant prostate cancer. Our previous studies have shown that Foxa2 is aWnt/beta-catenin target gene in prostates. Our preliminary study suggests a WntFoxa2CXCR4 axis that isinvolved in PCa bone metastasis, and activation of this axis provides survival mechanisms for PCa cellsfollowing androgen deprivation. The hypothesis is that the Wnt/beta-catenin activation of Foxa2 and CXCR4promotes progression to CRPCa and facilitates bone colonization by PCa cells, and that targeting this axis willprovide a novel treatment for PCa bone metastasis and relapse after androgen ablation.Last October 1st, I moved from Vanderbilt to LSU Health Sciences Center, Shreveport, LA. This award isundergoing an institutional transfer. Since funds have been tied up during the transition, I have not been ableto conduct any research related to this project since I moved to LSUHSC.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2015
Accession Number
AD1000971

Entities

People

  • Xiuping Yu

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Cancer
  • Culture Techniques
  • Department Of Defense
  • Electronic Mail
  • Information Operations
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tissues

Readers

  • Clinical Trial Research.
  • Prostate Cancer Biology.
  • Research Science/Academic Research