Purification Efficacy of Synthetic Cannabinoid Conjugates Using High-Pressure Liquid Chromatography

Abstract

In the current study, we successfully purified several synthetic cannabinoid (SC): dark quencher conjugates essential for the success of the synthetic cannabinoid detection platform developed at the US Army Research Laboratorys Weapons and Materials Research Directorate. The purification was conducted using high-pressure liquid chromatography and gradient screens to determine the most effective means of purifying the SC:dark quencher conjugates to obtain the highest yields and purity. The purity was verified using liquid chromatographycoupled mass spectroscopy and nuclear magnetic resonance.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2016
Accession Number
AD1001090

Entities

People

  • Abby L. West
  • Alexis M. Fakner
  • Mark H Griep
  • Shashi P. Karna

Organizations

  • United States Army Research Laboratory

Tags

Communities of Interest

  • Sensors
  • Weapons Technologies

DTIC Thesaurus Topics

  • Chromatography
  • Detection
  • Detectors
  • Drug Abuse
  • High Pressure
  • Liquid Chromatography
  • Magnetic Resonance
  • Mass Spectra
  • Mass Spectrometers
  • Mass Spectrometry
  • Materials
  • Measurement
  • Medical Personnel
  • Military Research
  • Nuclear Magnetic Resonance
  • Particle Size
  • Spectrometry

Readers

  • Molecular Photonics/Laser Physics
  • Molecular and Cellular Biochemistry
  • Neurotrauma and Rehabilitation Medicine.