Targeting Alpha5 Beta1 Integrin to Prevent Metastatic Breast Cancer Cell Invasion: PhScN Target Site Definition and Plasma Stability

Abstract

We proposed to test PHSCN and PhScN derivatives with modifications of the N or Ctermini, and/or cysteine side chain to determine the initial spatial constraints of the binding pocket of the ligand to its target site. This will aid in the selection of crosslinking agents, modifications, tag additions and strategies for determination of the target site(s) performed in Aim 2 and lay the foundation for determining the structure-activity relationships (SARS) of these inhibitors with the target

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
AD1001177

Entities

People

  • Philip S. Andrews

Organizations

  • Board of Regents of the University of Michigan

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biological Factors
  • Blood
  • Bone Diseases
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Synthesis
  • Chemistry
  • Confocal Microscopy
  • Diseases And Disorders
  • Endothelial Cells
  • Mass Spectrometry
  • Neoplasms
  • Peptides
  • Proteins

Readers

  • Molecular Biology and Genetics
  • Molecular and Cellular Biochemistry
  • Systems Analysis and Design