Vitamin E Supplementation in Burn Patients
Abstract
Our recent findings demonstrate that burn injury significantly depleted stores of vitamin E in adipose tissue of children by nearly 50% within one month of injury. The consequences of this severe and rapid depletion are unknown because adipose tissue alpha-tocopherol normally takes years to deplete. Our long-term goal is to improve the quality of life of the burn patient by preventing pathophysiology that may result from oxidative stress. The objectives of our proposal were to a) attenuate alpha-tocopherol depletion in burn patients by vitamin E supplementation, b) to prevent or reverse oxidative stress, c) to collect pilot data on the effect of vitamin E supplementation on lung function and impaired wound healing. We have administered vitamin E supplements to burn subjects for either days 1-15 or days 16-30 of the study (n=21 per group, 16-85 years, 40% total body surface area burns) at the Blocker Burn Unit (BBU) at the University of Texas Medical Branch(UTMB) in Galveston, the Burn Intensive Care Unit at Memorial Hermann Hospital (BICU-MHH) in Houston, and the Parkland Health and Hospital System Burn Unit (PHHS-BU) in Dallas.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1001194
Entities
People
- Hawkins H. Prough
- Jung‐Hee Lee
- Linda Sousse
- Perenlei Enkhbaatar
Organizations
- University of Texas Medical Branch