Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS
Abstract
The goals of this project are to test if measures of genetic diversity, microenvironmental diversity, and/or mammographic biomarkers can be used to predict which DCIS tumors are most likely to progress to invasive breast cancer. We have applied for and received ethical approval to carry out the study at our primary site, and have completed a series of pilot experiments to determine the best resource (Washington University) that we will use to perform the genomic sequencing of our tumors. We are currently evaluating and optimizing antibodies to measure microenvironmental diversity as well as algorithms for analyzing mammograpies. We have also filtered through our tissue banks to identify the appropriate cases for the full studies, and have even begun work to secure samples for our final validation study. Finally, we have recently published three papers supported by this study in Nature Reviews Clinical Oncology and Philosophical Transactions of the Royal Society. We are making rapid progress and anticipate no problems in meeting our 24 month milestones.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1001285
Entities
People
- Carlo Maley
Organizations
- University of California, San Francisco