Breaking the Neural Code
Abstract
This seedling proposed to use advanced imaging techniques to break the neuronal code that links the firing of neurons in the cerebral cortex with behavior. We proposed to use holographic two-photon excitation and microscopy in awake behaving mice to directly modify and create activity patterns in neurons of the primary visual cortex to alter perception and decision making. Our work combined sophisticated optical imaging and photo stimulation technologies with state-of-the-art computational detection of the activity with prediction and computation of the precise activity patterns that proved to be most effective at altering a simple visual behavioral choice. The Yuste and Paninski laboratories combined their efforts in this interdisciplinary project, with the ultimate goal of decoding and modulating the neuronal activity patterns by generating a closed-loop on-line experimental platform. We have completed all proposed tasks of the seedling and successfully completed preliminary closed-loop stimulation. Recent results are included in this final report. We have published 2 journal articles and have three manuscripts in submission form the funded work.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 21, 2015
- Accession Number
- AD1001385
Entities
People
- Darcy S Peterka
- Julia Sable
- Liam Paninaski
- Rafael Yuste
Organizations
- Columbia University