Novel Array-Based Target Identification for Synergistic Sensitization of Breast Cancer to Herceptin
Abstract
In this final comprehensive progress report we summarize that the major goal of our breast cancer program was achieved. We identified over 737 new and unique genes regulated by the HER2 oncogene in HER2-positive breast cancer cells. We showed which 113 of these genes are regulated in fresh breast cancer tissue leading to significantly increased or suppressed RNA expression. We showed that 58 of these genes are linked to the four pluripotency genes SOX2, NANOG, OCT3 AND OCT4 plus CREB1 suggesting that the HER2 oncogene promotes re-expression of these developmental genes which promote cancer stem cells in other solid tumors but not known to be regulated by HER2 in human bread cancer. These are novel and testable findings that significantly alter our view of HER2 in breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2010
- Accession Number
- AD1001432
Entities
People
- Daniel A. Mercola
Organizations
- University of California, Irvine